http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102988374-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4748 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 |
| filingDate | 2012-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102988374-B |
| titleOfInvention | Poly-lactic-co-glycolic acid-polylysine-polyethylene glycol-tetrandrine and daunorubicin copolymer nanoparticles as well as preparation method and application thereof |
| abstract | The invention discloses poly-lactic-co-glycolic acid-polylysine-polyethylene glycol-tetrandrine and daunorubicin copolymer nanoparticles as well as preparation method and application thereof. The method comprises the following steps of: dissolving a copolymer in an organic solvent (O), forming an oil-phase polymer, dissolving a medicine in an aqueous phase (W1), slowly adding the aqueous phase into the oil phase until primary emulsion (W1/O) is formed, rapidly adding the prepared primary emulsion into another aqueous phase (W2), performing multiple emulsion to form multiple emulsion (W1/O/W2), drying the nanoparticles subjected to multiple emulsion in an organic phase, centrifuging the solution through a high-speed refrigerated centrifuge, spinning the precipitate by using water, repeatedly operating twice, and preparing the PLGA-b-PLL-g-PEG coated tetrandrine and daunorubicin copolymer nanoparticles. The copolymer nanoparticle carrier is easy and convenient in preparation method, a medicine loading method is suitable for industrial production, and the environmental pollution is less. |
| priorityDate | 2012-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.