| abstract |
The present invention relates to compounds of general formula (I) and pharmaceutically acceptable salts, hydrates or solvates thereof, wherein R 1 , R 2 , R 3 , R 4 , m and n are as defined herein, which can be used alone or in combination with a One or more other pharmaceutically active compounds in combination for therapy, as JAK kinase and protein tyrosine kinase inhibitors for the prevention, treatment or amelioration of diseases and their complications, including e.g. psoriasis, atopic dermatitis, rosacea Nose, Lupus, Multiple Sclerosis, Rheumatoid Arthritis, Type 1 Diabetes, Asthma, Cancer, Autoimmune Thyroid Disease, Ulcerative Colitis, Crohn's Disease, Alzheimer's Disease, Leukemia, Eye Disease Examples are diabetic retinopathy and macular degeneration and other autoimmune diseases and indications where immunosuppression is required, eg in organ transplantation. |