http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102977120-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f501696709cd53f16cec9fbe026c284 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-08 |
| filingDate | 2012-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ae62ec3959dcebc0eb43566c2b1af7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3aafb8ca970bcec93b3845f544f3e58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_721f1f59980ca4dfc2964a1a4afc1a90 |
| publicationDate | 2015-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102977120-B |
| titleOfInvention | Method for preparing and crystallizing sulbactam pivoxyl |
| abstract | The invention provides a method for preparing and crystallizing sulbactam pivoxyl, and the method comprises the following steps of: (1) pumping a solvent into a reaction kettle, adding sulbactam acid into the solvent, controlling the temperature, stirring for dissolving, adding alkali into the mixture, controlling the reaction temperature, stirring for complete reaction, and then carrying out centrifugal drying to obtain sulbactam salt; and (2) suspending the sulbactam salt into the solvent, evenly stirring, dropwise adding chloromethyl pivalate, controlling the reaction temperature, adding a mixed solution of water and organic solvent into the mixture after the reaction is completely carried out, stirring, crystallizing and carrying out centrifugal drying to obtain the sulbactam pivoxyl. The method has the advantages that 1) the product is high in yield; 2) the product is crystalline solid, and is good in stability and high in purity; 3) the reaction time is short; 4) the reaction conditions are mild, and the method does not need catalyst and high-risk hydrogenation reaction; and 5) the product is simple in separation operation, can be directly filtered and separated after reaction, and does not need the steps, such as extracting, distilling, high-risk hydrogenation, refining and passing column, which are complicated in operation, so that the batch production period can be greatly shortened. |
| priorityDate | 2012-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.