http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102977027-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be2c55a9de09e08e3404c0a5a1ae4dc7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 |
| filingDate | 2012-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f91e4d2e4e362abe4c24ae7837e508f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_884464cca0163c695fb0dab4c917817e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6819f068b37ac6f1171bd973c7ba697 |
| publicationDate | 2015-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102977027-B |
| titleOfInvention | Preparation method of 5-aryl-3-trifluoromethyl-1H-pyrazole compound |
| abstract | The invention relates to a preparation method of a 5-aryl-3-trifluoromethyl-1H-pyrazole compound. The preparation method comprises the steps of: adding a catalyst, alkali and DABCO(1,4-diazabicyclo[2,2,2]octane) into a drying reactor, continuously adding 2-aryl-1-acetylene and 2,2,2-trifluoromethyl diazoethane into an organic solvent for completely reacting for 3-24h at the temperature of 0-50 DEG C, and washing, extracting and separating to obtain the 5-aryl-3-trifluoromethyl-1H-pyrazole compound, wherein the molar ratio of the 2-aryl-1-acetylene to the catalyst to the alkali to the DABCO to the 2,2,2-trifluoromethyl diazoethane is 1:(1-3):(1-3):(0.1-1):(2-10). The preparation method provided by the invention is simple, convenient and efficient for synthesizing trifluoromethyl pyrazole compounds and has the advantages of simplicity of operation, mild reaction condition, high yield, good substrate universality and high atom utilization rate. |
| priorityDate | 2012-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.