| abstract |
The present invention relates to antibody-drug conjugates and methods. The present invention relates to an antibody-drug conjugate compound of formula I: Ab-(LD) p I, wherein one or more maytansinoid drug moieties (D) are covalently linked to the antibody (Ab) via L, said Antibodies (Abs) bind ErbB receptors, or bind one or more tumor-associated antigens or cell surface receptors. These compounds are useful in methods of diagnosis or treatment of cancer, as well as other diseases and disorders. |