http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102964352-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c80367a92534e1a5daf43be44ac60ed |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 |
| filingDate | 2012-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24c21fbbc7f4cbccc1110759c2e26e2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1303d6a9b88a1646b6c98c8f3c996cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45045c003e61b240b9a870e01da5469d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c656ba78a829a4cc51ec9c6dee42e385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e45ca0e29ca6948bf98a535629b5c51 |
| publicationDate | 2015-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102964352-B |
| titleOfInvention | Chiral 2,3-dihydropyrrole[1,2-a] indole derivatives with biological activity and asymmetric synthesizing method thereof |
| abstract | The invention relates to chiral 2,3-dihydropyrrole[1,2-a] indole derivatives with a biological activity and an asymmetric synthesizing method thereof. The derivatives have a structure of a general formula I, in which R1 is hydrogen, 6-methyl, 7-methyl, 8-methyl, 7-methoxyl, 6-fluorine, 6-chlorine, 7-fluorine, 7-chlorine, 7-bromine or 7-benzyloxyl; R2 is methyl, ethyl, isopropyl, cyclohexyl, phenyl, benzyl, dimethyl tertiary butyl siloxy ethyl, benzosuccinimide ethyl or CH2CO2Me; R3 is phenyl, 4-methyl phenyl, 4-methoxyl phenyl, 4-fluorophenyl, 4-chlorphenyl, 4-bromophenyl, 3-bromophenyl, 2-fluorophenyl, 2-thienyl, styryl, ester group or cyclohexyl; and R4 is methyl, ethyl, isopropyl or benzyl. The derivatives are synthesized by Michael-semiacetalation cascade reaction of 3-substituted indole and beta, gamma-unsaturated alpah-keto ester catalyzed by copper trifluoromethanesulfonate and oxazoline ligand. |
| priorityDate | 2012-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 147.