http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102964297-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-3563 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2012-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102964297-B |
| titleOfInvention | The preparation method and detection method of a kind of Roflumilast raw material |
| abstract | The invention discloses the preparation method and detection method of a kind of Roflumilast raw material, the preparation method includes：Take 3 cyclo propyl methoxy, 4 difluoro-methoxy-benzoic acid SM 1, thionyl chloride, dimethylformamide and toluene mixing, generation acyl chloride reaction obtains intermediate 1,3 are taken again, 5 dichloro-4,4 aminopyridine SM 2, tetrahydrofuran and potassium tert-butoxide mixing, the tetrahydrofuran solution that salt-forming reaction obtains intermediate 2 occurs, after take intermediate 1, intermediate 2 and tetrahydrofuran mixing, amidation process occurs and obtains roflumilast crude product, roflumilast crude product is carried out it is refined to obtain the final product.The present invention is in view of the deficiencies of the prior art, the preparation process of Roflumilast raw material is optimized, make the effect of it is to diseases such as treatment COPD more notable, and establish system, complete, effective component differentiates and content assaying method, the quality of the medicine can be effectively controlled, so that it is guaranteed that its clinical efficacy. |
| priorityDate | 2012-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.