| abstract |
The invention discloses a method for effectively synthesizing a nitrile compound by reacting a copper salt, a ligand and a co-catalyst, a final oxidant such as with ammonia water under the mild condition in an alcohol and synthesizing multiple heterocyclic compounds with a one-pot method. In the method, the substrate adaptability is wide, the reaction time is short, the yield is high and the atom economy is high. Use of severe conditions, such as high temperature and high pressure and toxic starting materials is avoided; and the preparation method is simple in operation steps and less in corrosion on instruments, generates less waste gas, waste water and industrial residue, and is beneficial to further popularization and application, and industrial production. |