http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102961763-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0cb011d981829bdcc85a40133a181da8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-06 |
| filingDate | 2012-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_361f0a44b9bf05736fbc73cf031343d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_079547da80fd4f09f11de90ec9d6ee10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4b70f797003f1b9a5554a6b37130862 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b50f04bfa8d905d163d24fd22ae2d5df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c35c347af943482c2310b8b1a436ed0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23f3f52a66b918966f9f432a9fe08749 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27e40a4e318a3165edb329e6dfb64122 |
| publicationDate | 2014-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102961763-B |
| titleOfInvention | Paramagnetism metal complex magnetic resonance imaging contrast agent containing asparaginic acid-glucan and preparation method of contrast agent |
| abstract | The invention provides a paramagnetism metal complex magnetic resonance imaging contrast agent containing asparaginic acid-glucan and a preparation method of the contrast agent, to solve the problem that in the prior art the contrast agent is low in relaxation rate. According to the contrast agent, the glucan is used as a carrier; asparaginic acid is connected with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), and is further subjected to coordination with the paramagnetism metal ions in a mole ratio of 1:1 so as to obtain the complex. According to the preparation method of the paramagnetism metal complex magnetic resonance imaging contrast agent containing the asparaginic acid-glucan, the contrast agent with relatively higher relaxation efficiency is obtained by controlling the dosage ratio of reaction raw materials, the pH value of solution, the reaction temperature and the reaction time. The contrast agent can be used for magnetic resonance imaging; after the contrast agent imaging is accomplished, the asparaginic acid carried in the contrast agent has protection function on hearts, and therefore the contrast agent is an imaging contrast agent with double functions. |
| priorityDate | 2012-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.