| abstract |
The object of the present invention is to provide a method for preparing carboxylic acid derivatives by aromatic nucleophilic substitution, wherein the carboxylic acid derivatives have a carboxyl functional group, or a salt thereof reacts with the reactant MNu, the carboxylic acid derivatives The compound has a leaving group at the ortho position of the carboxyl functional group, the leaving group is preferably a fluorine or chlorine atom or a chiral or achiral alkoxy group, preferably a methoxy group, and the derivatives are not described Substitution with electron-withdrawing groups other than leaving groups (if any), where M is a metal and Nu is a chiral or achiral nucleophile, the aromatic nucleophilic substitution reaction is Carried out without catalyst and without protection/deprotection steps of the acid functions of the starting compounds. |