http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102952799-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca4bc87109c7b3600a347e3af3c9087b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02 |
| filingDate | 2012-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcbe35654ba409ef264fa56334426e57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ef4e910f502721e0612a5cb1437c6e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6dfb6332e30c8641c5e35349098b278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3518b3c938dce54ddef199c6e320fee |
| publicationDate | 2015-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102952799-B |
| titleOfInvention | Applications of gene and protein coded thereby to promotion of cell cytoplasm cleavage and cell proliferation as well as research and development of drugs |
| abstract | The invention discloses functions of an ALKBH4 gene and an ALKBH4 protein coded thereby in cytoplasm cleavage and cell proliferation and a potential application value in research and development of anti-cancer drugs for ALKBH4. The ALKBH4 protein is interacted with actin and non-muscle myosin (NM) II to demethylate actin K84mel, and the demethylation modification reaction is critical to combination of NM II on actin and slide of NM II along an actin fiber and has an effect on the cytoplasm cleavage efficiency. ALKBH4 gene silencing can cause excessive copying of a midbody, cell cleavage stage arrest and cytoplasm cleavage failure to finally cause cell apoptosis and multinucleate cell generation, the loss or inhibition of the ALKBH4 protein can cause a cell proliferation and migration defect, and finally, a cell is dead. Therefore, ALKBH4 can be used for the research and the development of the anti-cancer drugs. |
| priorityDate | 2012-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 233.