http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102936614-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_409f3c476296e90b614671626d1b5798 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-00 |
| filingDate | 2012-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f708526c10d0e8f5fcfd7652d2ea218c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44f629e3e18451359376d36f5953ae8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d18afc932a3b4298f89a278f67c90532 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7380fa038e36bada368e9a64d2dac05e |
| publicationDate | 2015-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102936614-B |
| titleOfInvention | Synthesis method of 7-alpha-methoxy-3-deacetylcephalothin benzathine |
| abstract | The invention provides a synthesis method of 7-alpha-methoxy-3-deacetylcephalothin benzathine. The method comprises the following steps of: (a) performing 7-methoxy substitution reaction between the cephalotin acid and the sodium methylate and halogenated agent in an organic solvent at (-100)-(-60) DEG C, and hydrolyzing the obtained 7-methoxy substitution product to obtain 7-alpha-methoxy-cephalotin acid; (b) transforming the 7-alpha-methoxy-cephalotin acid into sodium salt or ammonium salt in an aqueous solution; (c) performing enzymolysis reaction between the sodium salt or ammonium salt and the deacetylation curing enzyme in an aqueous solution at 10-40 DEG C to obtain a 3-deacetylation product; and (d) enabling the 3-deacetylation product to react with N,N-dibenzyldiaminediacetate in an aqueous solution to obtain the 7-alpha-methoxy-3-deacetylcephalothin benzathine. The method provided by the invention is milder in reaction conditions, simple and convenient to operate, environment-friendly and suitable for industrial production. |
| priorityDate | 2012-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.