| abstract |
The present invention provides a cationic liposome shown in formula I: wherein, R is a substituent shown in formula II, III, IV, V: R' is an alkyl group of C6~C40, a substitution of C6~C40 Alkyl, cholesteryl or cholic acid. The invention provides a novel degradable cationic liposome with good biocompatibility, which uses PAMAM as the hydrophilic head and two hydrophobic chain segments as the hydrophobic tail. The liposome has the excellent properties of PAMAM and liposome at the same time. At the same time, a preparation method of the cationic liposome represented by the formula (I) is provided. This method has strong versatility, and many compounds with similar structures can be obtained by this method. It also provides a methodological platform for studying the structure-property relationship of such compounds. |