http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102935235-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8eaf0e75177d288022d3cbabcc3ceada |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
| filingDate | 2012-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a7958e3684326e7d968e6e52f1faf93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3021e9f61b8731aa2c4f835631149807 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4139f2211198fa717a6c29fa96dd3723 |
| publicationDate | 2014-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102935235-B |
| titleOfInvention | Preparation method of modified casein drug-carrying controlled-release thin film |
| abstract | The invention relates to a preparation method of a modified casein drug-carrying controlled-release thin film. In the prior art that a drug-carrying material is made from the natural high molecular material, a drug-carrying medium is usually made from chitosan, starch and cellulose, while the research that the drug-carrying thin film is prepared by taking natural protein casein as the medium is hard to see in public reports. The preparation method takes casein as the drug-carrying medium, and comprises the following steps of: firstly, introducing nano-silica particles by the in-situ hydrolysis of ethyl orthosilicate, and introducing a silane coupling agent capable of stabilizing a system and improving the crosslinking degree of the thin film to prepare casein-base composite emulsion; and filming by drying the emulsion, and immersing the film into ibuprofen solution dissolved in organic solvent to form into the drug-carrying thin film by means of freeze drying after the adsorption reaches the balance. Therefore, a stronger acting force is formed between the active group of the composite emulsion and the active group of the drug to obtain the drug-carrying thin film of which the loading efficiency is greater than 60%, wherein the drug-carrying thin film is better in controlled-release performance, and has the potential application value. |
| priorityDate | 2012-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.