http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102935068-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab5a7b5f39157c7a9ce35b4db7b84162 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61J3-00 |
| filingDate | 2012-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0576faeb1530a5a98dfe06da180254af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62d272fb9233c805e6712dfe5a8f6bd0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b471fa3458348d6821be6b97e06ba209 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2395c493e41e187056b8957437ceb52f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b9a8c8760f3974a3f890a361e2f01d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f40bfa9136f42ae65dc20398c33aed41 |
| publicationDate | 2014-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102935068-B |
| titleOfInvention | Preparation method of liposome entrapping water-soluble medicines |
| abstract | The invention relates to a preparation method of a liposome entrapping water-soluble medicines. According to the invention, a water-soluble medicine is dissolved in amino-acid-structure-containing high-molecular hydrophilic colloids such as gelatin, collagen or albumin; poloxamer is added and the mixture is well mixed, such that a W/W type colloidal solution is formed; the solution is lyophilized; the formed lyophilized powder is transferred into a tert-butanol solution containing a liposome material, and the mixture is well dispersed; and the mixture is subjected to lyophilization, such that high-entrapment-efficiency liposome entrapping the water-soluble medicine is formed. According to the liposome preparation method, W/W type colloid is combined with a two-step lyophilization preparation technology, such that problems such as low water-soluble medicine load, low entrapment efficiency and poor stability of existing preparation methods of liposome entrapping water-soluble medicines are solved. The method provided by the invention is used for preparing liposome used for entrapping water-soluble medicines, and is especially suitable for preparing liposome used for entrapping poor-thermal-stability or macromolecular medicines. The method can also be used for covering medicine bitterness or odor, and for separating medicines from other components. |
| priorityDate | 2012-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 542.