| abstract |
The present invention provides pyrazol-4-yl-heterocyclyl-carboxamide compounds of formula I, including stereoisomers, geometric isomers, tautomers and pharmaceutically acceptable salts thereof, wherein X is thiazolyl, epi Corolinyl, pyridyl, pyrimidinyl or fluoro-pyridyl rings, which are useful for inhibiting Pim kinases, and for treating disorders such as cancers mediated by Pim kinases. Methods of using compounds of formula I for in vitro, in situ and in vivo diagnosis, prevention or treatment of said disorders or associated pathological conditions in mammalian cells are disclosed. |