http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102925528-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d70cda22ec536383d5602f54d860005e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-182 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2012-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e274cfe7bdcd40fa86ed013a2ac5424a |
| publicationDate | 2013-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102925528-A |
| titleOfInvention | A kind of method for preparing the intermediate of L-praziquantel and L-praziquantel |
| abstract | The present invention provides a method for preparing L-praziquantel intermediate and L-praziquantel, comprising the following steps: (a) hydrolyzing the compound of formula (2) at 0-80°C under the action of nitrilase, Obtain the mixture of the compound of formula (3) and the compound of formula (4); isolate the compound of formula (4) from the mixture, i.e. the intermediate of L-praziquantel; (b) make the compound of formula (4) undergo Catalytic hydrogenation reaction to obtain the compound of formula (5); (c) making ring formation reaction between the compound of formula (5) and chloroacetyl chloride in an organic solvent to obtain the compound of formula (6) L-praziquantel. The method uses nitrilase's high stereo, site and regioselectivity, and catalyzes the chemically synthesized racemate to carry out the hydrolysis synthesis reaction to obtain a mixture of reacted and unreacted optical isomers, and then further obtain L-praziquantel . The process of the method is very mature, the raw materials are easy to obtain, and the cost is low, so it is applicable to industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104557911-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014131247-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104557911-A |
| priorityDate | 2011-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.