http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102924474-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71023d025b821a5c9b9ad222aca54f86 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2012-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_194950f47151972b13359c99f42273e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f7b1a70025a341a6697383015e595c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33d23a3296af0a6a4b8c91a708e9da0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffe8c6437e1bfcc8422ab081e9fa6d65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01c77571d59109fe57215086554a1075 |
| publicationDate | 2015-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102924474-B |
| titleOfInvention | Preparation method of crystal form I of clopidogrel hydrogen sulfate |
| abstract | The invention provides a preparation method of a crystal form I of clopidogrel hydrogen sulfate. The preparation method comprises the following steps of (1) dropwise adding concentrated sulfuric acid or 2-methyltetrahydrofuran solution of the concentrated sulfuric acid into 2-methyltetrahydrofuran solution of clopidogrel free base to obtain mixed solution, wherein the temperature of the mixed solution is controlled to range from -10 DEG C to 5 DEG C when the dropwise adding is performed; and (2) heating the mixed solution to the temperature of 10-35 DEG C, performing crystal precipitation with stirring, separating precipitated crystals, and drying the precipitated crystals to obtain the crystal form I of the clopidogrel hydrogen sulfate. The preparation method is simple, easy to implement, good in reproducibility and suitable for industrial production. The prepared crystal form I of the clopidogrel hydrogen sulfate has the advantages of being high in crystal form purity and high-performance liquid chromatography (HPLC) purity, low in cost, good in stability, high in solvent recovery, environment-friendly and the like. |
| priorityDate | 2012-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.