| abstract |
The invention provides a water-phase green preparation method for a 1,3-disubstituted-3-aryl allyl compound and application of the 1,3-disubstituted-3-aryl allyl compound. The method comprises the following step of: reacting an allyl carbonate compound with an aryl boric acid compound in a water phase by using Pd(OAc)2 as a catalyst in the absence of any ligand to prepare the 1,3-disubstituted-3-aryl allyl compound. The palladium catalyst used in the method is easy to obtain and a reaction condition is mild; a chiral product having inversed configuration can be obtained by using a chiral substrate, so that the chiral conversion rate is high; and the 1,3-disubstituted-3-aryl allyl compound is easy to convert and derivate and can be used for preparing aryl propionic acid class anti-inflammatory pain relievers. |