| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5d344aaf26e1c850e91999a42852c9f |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2012-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52e74c93f9072ee28ea64363f659799b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8002117dcb7f4a0e48b368a850911745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dec84860a0153f4b76c3778e39a5fee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ae12fcde7d8671114d67191cc812626
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c30f2d2a39962ee64351c03685d72f0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94418a70ad1f9825b33adc254fa8c710
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6d82f0db130954afe38dd38e23cb309
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0515af731bfc21ce3eeca022f23c86bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45ad961d50cb6e692736ced39bf8473b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21549e445de79fb49d4ff8d2a20f5dab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecd912102525286c4e1c2663e63f8afc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a366c8dc6cfd19fd2600508d3e0d106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fe752f757e6ecd23c7cb8ec80f117ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cb81ae1418dedf953fe023b98f606b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18e5d289e8efc2f5a2cc61c5ef9d2cdc |
| publicationDate |
2014-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-102911940-B |
| titleOfInvention |
Small ribonucleic acid interference molecule for specifically inhibiting NK (Natural Killer) cell receptor KIR3DL1 and application of small ribonucleic acid interference molecule |
| abstract |
The invention discloses a small ribonucleic acid interference molecule for specifically inhibiting an NK (Natural Killer) cell receptor KIR3DL1 and an application of the small ribonucleic acid interference molecule. The genbank login number of the mRNA of the targeted KIR3DL1 of the small ribonucleic acid interference molecule for specifically inhibiting the NK cell receptor KIR3DL1 is NM_013289. A large amount of experiments show that the siRNA fragment can remarkably inhibit the expression of the receptor KIR3DL1 of an NK cell membrane, and the siRNA subjected to various chemical modifications has the same effect of inhibiting the expression of the receptor KIR3DL1. The expression level of IFN-gamma and TNF-alpha cell factors in an NK cell can be remarkably increased after the expression of the receptor KIR3DL1 is inhibited. Meanwhile, the killing activity of the NK cell can be remarkably enhanced after the siRNA is transfected. Therefore, the small ribonucleic acid interference molecule for specifically inhibiting the NK cell receptor KIR3DL1 can be applied to preparation of anti-aids drugs. |
| priorityDate |
2012-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |