http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102911233-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a25d992bdb1081326b846d7aedcd76e6 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2012-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11a6d4ecea538501337ded2c4bff49dc |
| publicationDate | 2013-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102911233-A |
| titleOfInvention | A kind of synthetic method of medroxyprogesterone |
| abstract | The invention discloses a method for synthesizing medroxyprogesterone. The method comprises: 1. 17α-hydroxyprogesterone and ethylene glycol undergo ketal reaction under the catalysis of p-toluenesulfonic acid to obtain a ketal product; 2. The ketone is reacted with epoxy under the action of the peracetic acid solution of anhydrous sodium acetate to obtain the epoxy; 3. The epoxy and methylmagnesium bromide are subjected to Grignard reaction and then hydrolyzed with dilute sulfuric acid to obtain the Grignard; 4. The Grignard compound was deprotected by hydrolysis with glacial acetic acid to obtain 5α, 17α-dihydroxy-6β-methyl progesterone; 5. Under the action of hydrogen chloride, 6α-methyl-17α-hydroxyprogesterone was obtained through hydrogenation transposition reaction; 6. , 6α-methyl-17α-hydroxy progesterone and acetic acid and acetic anhydride undergo acetylation reaction to obtain medroxyprogesterone. In the reaction process of the invention, the use of noble metal catalyst palladium carbon is avoided, the cost of auxiliary materials and recovery cost are greatly reduced, the reaction conditions of each step are mild, there is no violent heat release and gas release, and the production safety is good. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106866766-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113583074-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106866766-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114380878-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113583075-A |
| priorityDate | 2012-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4154748-A |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID465230945 |
Total number of triples: 17.