http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102898449-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c7c582c58ebb902c3111171ec32c641 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 2012-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7d751088e178b972afc0e88abe3a8d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15eac2b2e4aad5e83523f35756f58603 |
| publicationDate | 2013-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102898449-A |
| titleOfInvention | A kind of method of synthetic crizotinib intermediate |
| abstract | The present invention belongs to the technical field of drug synthesis, and specifically relates to a method for synthesizing an intermediate of Crizotinib . ) as raw material, react with 4- nitropyrazole to prepare compound 3 ; b ) use hydrazine hydrate to reduce the nitro group to obtain amino compound 4 ; In the presence of benzoyl oxide , react with boronate compound 5 to prepare Crizotinib intermediate ( 1 ). Compared with the existing synthetic method, the inventive method has the following advantages: use the diazotization method to synthesize the boric acid ester product, compared with the existing method, that is, the Pd- catalyzed Miyaura boronation method, this method avoids the use of expensive palladium Catalyst and ligand, and has the advantages of mild reaction conditions, high yield, simple operation, cheap and easy to obtain raw materials, short reaction cycle, etc., and is very easy for industrialized large-scale production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017197604-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111285890-A |
| priorityDate | 2012-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.