abstract |
The invention discloses a kind of such as formula the quinazoline derivant shown in I, its pharmacy acceptable salt, or their enantiomer, diastereomer, tautomer, raceme, solvate, metabolic precursor thereof or prodrug.The invention also discloses its preparation method, intermediate, containing its pharmaceutical composition and application.Quinazoline derivant of the present invention has preferably anti-tumor activity. |