http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102887913-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c5cb5064c0abcb508d6df22af68b5c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e13dca5300dd2ead65f991d697cdd5ad |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 2012-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80411c8e101fc87f99570dc6a6457116 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de3821a93a887427f8d8eadd24e426cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eabbef17312fbbda0cb57b6180f96403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14cf7581c8a01bd059ea314a5ffd9662 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0a0486854ca9dca00e8cf06689bb2fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14ab274069207ea0a94de6064f767dd4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3af6b6430ed3fc3af20e026944d2ff07 |
| publicationDate | 2015-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102887913-B |
| titleOfInvention | Method for synthesizing 4-dihydroxyborane-2-fluorophenylalanine |
| abstract | The invention discloses a method for synthesizing a 4-dihydroxyborane-2-fluorophenylalanine, wherein the method comprises the following steps of taking p-iodotoluene as a raw material, carrying out nitratlon reaction and bromination reaction in sequence on the raw material to obtain p-iodo-o-nitrobenzyl bromine, firstly substituting the p-iodo-o-nitrobenzyl bromine with diethyl sodium acetamidomalonate to obtain diethyl 2-acetamido-2-(4-iodo-2-nitrobenzyl) malonate, and then reacting with ammonium tetrabutyl fluoride to obtain fluorinated diethyl 2-acetamido-2-(4-iodo-2-fluorobenzyl) malonate, carrying out Suzuki coupling reaction on the obtained fluorinated product and bisdiboron under an inert atmosphere, hydrolyzing the obtained diethyl 2-acetamido-2-(4-valerylboron-2-fluorobenzyl) malonate to obtain the 4-dihydroxyborane-2-fluorophenylalanine. The method provided by the invention is not necessary to use fluorine gas; the method provided by the invention has low requirement to production equipment; the reaction is carried out under common experimental conditions; the method provided by the invention has the advantages of simple synthesis step, high yield, high product purity and easy purification. |
| priorityDate | 2012-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.