| abstract |
The invention discloses an L-phenylglycine derivative shown in a formula I, wherein in the formula, R1 is an amino-protecting group, R2 is -NO2, -NH2 or -NHCO(CH2)nR4, n=1-8, R4 is hydrogen, halogen, hydroxy, acyloxy, C1-C8 alkoxy, sulfhydryl, substituted sulfhydryl, amino, substituted amino or nitrogen-containing heterocyclic group, R3 is -OR5 or NR6R7, R5 is hydrogen, C1-C8 alkyl or substituted C1-C8 alkyl, R6 and R7 independently are hydrogen, hydroxy, C1-C8 alkyl or substituted C1-C8 alkyl. The L-phenylglycine derivative provided by the invention has certain PPRE agonistic activity, and the relative PPRE agonistic activity of part of the compound reaches to 32.91 to 120.42 %. The L-phenylglycine derivative can be used for preparing a PPRE agonist and also is a good precursor molecule of anti-diabetic drugs. |