http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102887830-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c324d47ff372493b35f171b221f8883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-16 |
| filingDate | 2012-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d3a64bda1496e1fdf3b0889200b6093 |
| publicationDate | 2013-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102887830-B |
| titleOfInvention | Preparation method of phenoxybenzamine hydrochloride |
| abstract | The invention relates to a preparation method of phenoxybenzamine hydrochloride, which comprises the following steps: reacting phenol with methyl epoxyethane to obtain 1-phenoxy-2-hydroxy propane; reacting 2-nitrobenzenesulfonyl chloride with benzylamine to obtain N-2-nitrobenzenesulfonyl benzylamine; reacting the obtained 1-phenoxy-2-hydroxy propane with the N-2-nitrobenzenesulfonyl benzylamine to obtain N-benzyl-N-(1-methyl-2-phenoxyethyl)-2-nitro-benzsulfamide; converting the N-benzyl-N-(1-methyl-2-phenoxyethyl)-2-nitro-benzsulfamide into N-(1-methyl-2-phenoxyethyl) benzylamine; reacting the obtained N-(1-methyl-2-phenoxyethyl) benzylamine with 2-bromoethanol to obtain benzyl-(1-methyl-2-phenoxyethyl) ethanol; and dissolving benzyl-(1-methyl-2-phenoxyethyl) ethanol in a solvent, introducing hydrogen chloride gas, dropwisely adding thionyl chloride, and performing reflux reaction to obtain phenoxybenzamine hydrochloride. |
| priorityDate | 2012-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.