| abstract |
A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents one to three groups selected from substituent A (substituent A: hydroxyl, halogenated, cyano group, nitro, amino, carboxyl, C1 to C3 alkyl, etc.) substituted C1 to C6 alkyl, etc.; R 2 , R 3 and R 8 each independently represent a hydrogen atom or C1 to C3 alkyl; R 4 , R 5 , R 6 , R 7 , R 9 and R 10 each independently represent a hydrogen atom and the like; R 11 represents a hydrogen atom and the like, which have TAFIa enzyme inhibitory activity and are used for myocardial infarction, angina pectoris, acute Drugs for coronary artery syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, etc. |