http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102875586-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e2ba784a11bf94f0d7af0b295a8c05 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 |
| filingDate | 2011-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_628e85b8cf062d985c6a6962a5054590 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b7330558e4fdd977f438c712c0b6742 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8edea921c3678bccc01b82900e870c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ae6445a63ac82f20de953757c925e08 |
| publicationDate | 2013-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102875586-A |
| titleOfInvention | A kind of preparation method of limaprost key intermediate |
| abstract | The invention discloses a preparation method of a key intermediate of limatoprost. Specifically, a chiral compound of formula I and a preparation method thereof are provided, the method comprising steps: (1) reacting a compound of formula 3 and a compound of formula 4 to obtain a compound of formula 5; (2) reacting a compound of formula 6 with a compound of formula 5 compound reaction to obtain a compound of formula 7; (3) mixing a compound of formula 7 with a compound of formula 8 to obtain a compound of formula 1; and (4) reacting a compound of formula 1 with a reducing agent, and the obtained crude product is separated and purified by column chromatography , to obtain the compound of formula 2; (5) reacting the compound of formula 2 with the protecting agent removing agent to obtain the compound of formula 9. The definitions of each structural formula and substituent are as described in the description. The method of the invention has mild reaction conditions, and can easily and efficiently prepare high-purity chiral compounds. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109071427-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014040457-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2017264102-B2 |
| priorityDate | 2011-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.