| abstract |
The invention discloses an industrial production method of difluoroacetate. The method is to generate difluoroacetate through difluoroacetamide and lower alcohol under the catalysis of strong acid, and the product selectivity of the reaction reaches more than 95%. , which is characterized in that: a secondary amine that is easy to recover in industry and can be operated continuously is selected to prepare dichloroacetamide, and a solvent is selected to solve the difficulty that the fluorine substitution reaction is difficult to occur in the case of providing a combination of common solvents and catalysts , the solvent also has the function of a phase transfer agent, low cost and easy to recycle. |