http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102871994-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167 |
| filingDate | 2012-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102871994-B |
| titleOfInvention | Flurbiprofen acetaminophen ester cyclodextrin inclusion compound and preparation method thereof |
| abstract | The present invention relates to Flurbiprofen acetaminophen ester cyclodextrin inclusion compound and preparation method thereof, this anti-inflammatory and antalgic prodrug main component is novel compounds Flurbiprofen acetaminophen ester, by adopting cyclodextrin inclusion compound technique, Flurbiprofen acetaminophen ester is dissolved in organic solvent, add in cyclodextrin or derivatives thereof aqueous solution, stir, after dry, form clathrate soluble in water.Clathrate can be mixed and made into oral tablet with suitable adjuvant further, or capsule.The present invention can enlarge markedly drug solubility and dissolution rate, after process, the dissolubility of medicine in water improves 10 ~ 100 times than crude drug, in dissolution medium, the cumulative defaultlogic of 45 minutes also improves greatly, therefore which improves the oral absorption rate of hydrophobic drug Flurbiprofen acetaminophen ester. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3512511-A4 |
| priorityDate | 2012-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.