http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102864203-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_491c4f0b9398b3817bd34f14bb94ba71 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P11-00 |
| filingDate | 2012-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f5139e94646f71f3c34ee40377f3376 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d36920c491debe5e35af9c21c8b3c03b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0c01af1b398ab1f93eff041d86611a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb96744c30047fc1457630b256a53d22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e382d880545a419dde0d212c817d33f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c08a5b1239d19a490e8da9d53a2dba9d |
| publicationDate | 2013-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102864203-A |
| titleOfInvention | A kind of preparation method of antihypertensive drug intermediate |
| abstract | The invention discloses a method for preparing D-3-acetylmercapto-2-methyl-propionic acid, an important intermediate of antihypertensive drugs. The method uses 2-methyl methacrylate and thioacetic acid as starting materials to obtain racemic 3-acetylmercapto-2-methyl-propionic acid methyl ester through condensation reaction, and then obtains D through enzymatic resolution. - 3-acetylmercapto-2-methyl-propionic acid. In addition, the invention also discloses a method for racemizing L-3-acetylmercapto-2-methyl-propionic acid methyl ester. The enzyme resolution and chemical racemization of the invention has the advantages of simple operation, suitability for industrial production, and high optical purity of the product. |
| priorityDate | 2012-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.