| abstract |
The invention provides a cisplatin complex, which is formed by coordinating cisplatin with a polymer having the structure of formula (I). The structured polymer undergoes a complex reaction in an aqueous medium to form a cisplatin complex. The cisplatin complex has good biocompatibility and is degradable; the polymer side chain is grafted with polyethylene glycol, so the prepared cisplatin complex has good solubility; when it is soluble in water In the medium, cisplatin is protected by the hydrophilic polyethylene glycol segment and the hydrophobic amino acid segment, which can effectively avoid the sudden release of cisplatin due to the influence of the blood circulation system after intravenous injection, and improve the coordination of cisplatin. material stability. In addition, the carboxyl group contained in the cisplatin complex provided by the present invention is sensitive to pH value, and tends to be deprotonated in a low pH value environment, which is conducive to promoting the release of drugs and improving the curative effect of drugs. |