http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102863434-B

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b26e17432236aa949f62b08733832285
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12
filingDate 2012-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2014-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_413e724675443db678884e1d16234836
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7f23f83da0b945df1f87a0384d31c09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85bd9842407f8efc65f46c091955e6e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1818cba9689657499e79582717920f5
publicationDate 2014-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-102863434-B
titleOfInvention Synthetic method of nifuratel
abstract The invention belongs to the field of medicine synthesis, and discloses a synthetic method of nifuratel. The synthetic method of nifuratel is to carry out ring closing reaction under the alkaline condition of sodium methoxide, therefore, the metallic sodium can be avoided being used, and the safety in production can be ensured; meanwhile, the reaction is easy to generate, the process is easy to control, high yield of the synthesized nifuratel is achieved, few impurities are generated, and the quality is stable; and moreover, the synthetic method of nifuratel is simple in operation, and the raw material is easy to obtain; the used solvent and the raw material out of the reaction can be recycled along with low cost; no waste liquid is generated in each step of the reaction; the pollution is greatly reduced; and the synthetic method is suitable for industrial production.
priorityDate 2012-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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