http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102858755-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 |
| filingDate | 2011-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102858755-B |
| titleOfInvention | 1,2,4-triazole derivative and anti-mycobacterium activity thereof |
| abstract | The invention provides the propargylation 1,2 being selected from formula I, the antitubercular compounds of 3 triazole species, wherein X is sulphur (S) or sulfone (A), and n, m represent integer 0 or 1 independently, and condition ' n ' to be 1, when ' m ' is 1; R1 is hydrogen; Optionally by C1-C6 straight or branched alkyl that aryl replaces; Halogen; Or optionally by the aryl of-OCH3, halogen and nitro replacement; R2 and R3 is selected from the group be made up of the following: hydrogen, optionally be selected from the C1-C6 alkyl of heterocyclic substituted of heteroatomic 5 to 6 annular atomses of oxygen, sulphur, nitrogen containing one to three, this heterocycle can be replaced by following group: alkyl, aralkyl, straight or branched thiazolinyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl group or propargyl, it is made up of 1 to 6 carbon atom; Z is optionally selected from the C1-C6 alkyl of heterocyclic substituted of heteroatomic 1 to 6 annular atoms of oxygen, sulphur, nitrogen containing one to three, described heterocycle can be replaced by following group: aralkyl, straight or branched thiazolinyl, substituted alkenyl, alkynyl, substituted alkynyl, allyl group or propargyl, it is made up of 1 to 6 carbon atom; Condition ' m ' to be 1, and when ' n ' is 0; R1 is selected from the group be made up of the following: hydrogen, halogen, the C1-C6 straight or branched alkyl optionally replaced by aryl or optionally by aryl that-OCH3, halogen and nitro replace; R2 and R3 is selected from the group be made up of the following: hydrogen, optionally be selected from the C1-C6 alkyl of heterocyclic substituted of heteroatomic 5 to 6 annular atomses of oxygen, sulphur, nitrogen containing one to three, this heterocycle can be replaced by following group: alkyl, arylalkyl, straight or branched thiazolinyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl group or propargyl, it is made up of 1 to 6 carbon atom; Z is selected from the group be made up of the following: halogen, optionally be selected from the C1-C6 straight or branched alkyl of heterocyclic substituted of heteroatomic 1 to 6 annular atoms of oxygen, sulphur, nitrogen containing one to three, wherein said heterocycle can also be replaced by halogen, alkyl, aralkyl. |
| priorityDate | 2010-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.