| abstract |
The invention relates to the medicament field, and particularly relates to a series of integrin blockers which can inhibit tumor angiogenesis, have integrin affinity and bonding capability, and can be used for prevention and treatment of solid tumor and rheumatoid arthritis. The polypeptides particularly are: polypeptide I, polypeptide II, and polypeptide III (shown in Seq NO. 1, Seq NO. 2, and Seq NO.3); the polypeptides can be used for treatment of solid tumor and rheumatoid arthritis. The application of the three integrin blocker polypeptides in preparation of medicaments for treating tumor is characterized in that the tumor is primary or secondary cancer, melanoma, and sarcoma derived from human head and neck, brain, thyroid, esophagus, pancreas, lung, liver, stomach, breast, kidney, gallbladder, colon or rectum, ovary, cervix, uterus, prostate, bladder, and testis. |