| abstract |
The present invention relates to a kind of GHRP.The invention discloses peptide or peptide mimics class compound and its pharmaceutically acceptable salt with lower formula (I) structure, the material can be used as GHRP analogs：R 1 ‑A 1 ‑A 2 ‑A 3 ‑A 4 ‑A 5 ‑R 2 (I), wherein A 1 It is Aib, Apc or Inp；A 2 It is D Bal, D Bip, D Bpa, D Dip, D 1Nal, D 2Nal, D Ser (Bzl), or D Trp;A 3 It is D Bal, D Bip, D Bpa, D Dip, D 1Nal, D 2Nal, D Ser (Bzl), or D Trp;A 4 It is 2Fua, Orn, 2Pal, 3Pal, 4Pal, Pff, Phe, Pim, Taz, 2Thi, 3Thi, Thr (Bzl);A 5 It is Apc, Dab, Dap, Lys, Orn, or lacks；R 1 It is hydrogen, (C 1‑6 ) alkyl, (C 5‑14 ) aryl, (C 1‑6 ) alkyl (C 5‑14 ) aryl, (C 3‑8 ) cycloalkyl, or (C 2‑10 ) acyl group；R 2 It is OH or NH 2 .The invention also discloses its pharmaceutical composition and its application method. |