| abstract |
The invention provides a preparation method of an aripiprazole pharmaceutic preparation, which comprises the following steps: dissolving aripiprazole in an acidic solution containing an acidifying agent to prepare a drug-containing acidic solution; then performing wet granulation or preparing a suspension by the drug-containing acidic solution, an alkalizer and an auxiliary material to obtain the aripiprazole pharmaceutic preparation; the auxiliary material comprises an anti-oxidant. The invention also provides an aripiprazole pharmaceutic preparation prepared by the method. The aripiprazole pharmaceutic preparation obtained by the preparation method of the invention has significantly reduced amounts of related materials, good dissolution property and stability, high bioavailability, less individual difference, and improved wetability and content uniformity of drugs which are difficult to dissolve. The method of the invention is simple in operation, and low in cost, requires no special equipment, and is easily applicable to industrial production; especially, the method eliminates the effect of raw material forms on preparation quality, and avoids defects of severe pollution, great loss, and severe potential safety hazard caused by aripiprazole pretreatment. |