| abstract |
Disclosed are a mixture, a dissolving solution and a pharmaceutical agent each comprising a thermophilic microorganism, which enable the regulation of mucous membrane immune system genes and genes relating to the metabolism in the intestine and the liver. Each of the mixture, the dissolving solution and the pharmaceutical agent is produced by fermenting an organic material containing a thermophilic microorganism, which is a microorganism capable of regulating the expression of at least one gene selected from mucous membrane immune system genes, genes relating to the metabolism in the intestine and genes relating to the metabolism in the liver in an animal when administered to the animal, at a temperature ranging from 50 to 90 DEG C inclusive, wherein at least one microorganism selected from thermophilic microorganisms belonging to the genera Bacillus, Oceanobacillus, Paenibacillus, Anoxybacillus, Lysinibacillus, Methanopyrus, Geogemma, Pyrolobus, Pyrodictium, Hyperthermus, Pyrococcus, Pyrobaculum, Thermococcus, Aeropyrum, Aquifex, Thermotoga, Thermodesulfobacterium, Thermus, Geobacillus, and Thermomyces is contained as the thermophilic microorganism. |