| abstract |
The invention belongs to the field of pharmaceutical chemicals, relates to a 2,4-diaryl thiazole derivative, and a pharmaceutical composition, a preparation method and application of the 2,4-diaryl thiazole derivative, and in particular relates to a compound shown in the formula I or a pharmaceutically acceptable salt of the compound, wherein R1 is of a structure shown in the formula II or III, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from hydrogen, hydroxyl, C1-C6 straight-chain or branched-chain alkyl, C1-C6 straight-chain or branched-chain alkoxy, substituted or unsubstituted benzyloxy, and halogen atoms (F, Cl and Br); when single bond is represented, X is selected from NH, S, O, CH2, SCH=CH, CH=CH, N=CH and CH=N; when double bond is represented, X is selected from N and CH; Y is selected from NH, S, O, CH2, CH=CH, N=CH and CH=N; Z is selected from NH, S, O, CH2, CH=CH, N=CH and CH=N. The pharmaceutical composition disclosed by the invention can effectively inhibit tumor cells and has prospect in antineoplastic drugs. |