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filingDate 2012-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2014-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea9883068599c361b7afd8b1410050bc
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publicationDate 2014-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-102838571-B
titleOfInvention Andrographolide derivative containing gamma-subunit butenolide, synthetic method and application thereof
abstract The invention discloses a novel andrographolide derivative, and in particular relates to an andrographolide derivative containing gamma-subunit butenolide, a synthetic method and application thereof, belonging to the field of pharmaceutical chemistry. The andrographolide derivative has the structural formula shown in the description, the synthetic method is simple and convenient, the condition is mild, the deprotection of functional group protection does not need, the andrographolide derivative can be directly and conveniently prepared, and the yield is high. The in vitro antibacterial activity evaluation result shows that the novel andrographolide derivative provided by the invention has a distinct effect on inhibiting fungi, such as candida albicans, so that the novel andrographolide derivative can be utilized to prepare the antifungal medicines.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019166003-A1
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