http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102827224-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-12 |
| filingDate | 2011-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102827224-B |
| titleOfInvention | The synthesis of a kind of decitabine and industrialized preparing process |
| abstract | The present invention relates to synthesis and the industrialized preparing process of a kind of decitabine; i.e. with 2 deoxidation D ribose as raw material; react with methanol and obtain first glycosides; 3; 5 dihydroxy are protected with 9 fluorenylmethyloxycarbonyls, then obtain 1 chlorine fluorenes sugar with hcl reaction, and 1 chlorine fluorenes sugar 5 azepine cytosine with silanization again react; then Deprotection, obtains decitabine after refining.It is characteristic of the invention that 1 chlorine fluorenes sugar need not butter of tin in 5 azepine cytosine condensation reactions of silanization, it is to avoid the problem of heavy metals exceeding standard in crude drug；Control amount and the reaction condition of Trimethylsilyl trifluoromethanesulfonate simultaneously, make β body burden in product increase. |
| priorityDate | 2011-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.