| abstract |
The invention relates to a preparation method of an iohexol impurity shown in Formula (1) 5-[N-(2, 3-dihydroxy-propyl) acetamido]-3-N-(2, 3-dihydroxy-propyl)-2, 4, 6-triiodo-1, 3-benzenedicarboxamide. Due to synthesis of the iohexol impurity, a reference substance can be provided for qualitative and quantitative analysis of iohexol impurities, the quality standards of iohexol can be improved, and important guiding significance can be achieved for safe use of the iohexol. |