| abstract |
The present invention relates to a thiadiazole derivative having DPP-IV inhibitory activity represented by formula I, its preparation method, its pharmaceutical composition, and its use in treating diseases benefited from DPP-IV inhibition, especially for the treatment of Type II diabetes use. The thiadiazole derivatives provided by the invention have very good DPP-IV inhibitory activity. And it has a very good level of metabolism in vivo and a very suitable half-life in vivo, and is expected to become a suitable DPP-IV inhibitor drug. |