http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102796169-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b9ed41ec71e1e3d004841f54c9eabd8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 |
| filingDate | 2011-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_310205baf5c2fc3564c67a26b238d27f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e81fda2445afb1a1f12a9f5f51c764e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_206b423887738cb36e3dc8511860b8b6 |
| publicationDate | 2014-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102796169-B |
| titleOfInvention | Double saturated aliphatic chain alcohol Glu-Asp-Gly-Asp tetrapeptide esters and preparation method and application thereof |
| abstract | The invention relates to six double saturated aliphatic chain alcohol Glu-Asp-Gly-Asp tetrapeptide esters which are shown as a general formula I and have immunosuppressive activity, and a preparation method thereof. The general formula I is Glu-Asp-Gly-Asp[OCH2(CH2)nCH3]-OCH2(CH2)nCH3, wherein n is 6, 8, 10, 12, 14 or 16. By studying inhibition effects of aliphatic chain alcohol on proliferation reaction of a splenic lymphocyte mitogen and the phagocytic activity of a macrophage, and the survival time of a mouse subjected to opisthotic cardiac transplantation, experimental results further show that the compounds have a good immunosuppressive effect, and a wide application prospect in preparation of immunosuppressive medicines. |
| priorityDate | 2011-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.