http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102796105-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d217957b3db7b40702c44db53445bef6 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2012-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf0d5b17df9219b28db0eea29944ad40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68739c75b22b429ac3c9c13fc6952eec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1c65df8e5e4340998ecf70862224845 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf3a9dd6ce912c8fb9721d0f8dccd7a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d172b63b8c015bb8fe38d4bf1899aa88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f52977832ea5573860908d3905f4f2e0 |
| publicationDate | 2014-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102796105-B |
| titleOfInvention | 2, 5, 6, 7-tetrahydropyrrolo[3, 4-c] pyridazine-3-one, its derivative and synthesis method thereof |
| abstract | The invention relates to a medicinal intermediate 2, 5, 6, 7-tetrahydropyrrolo[3, 4-c] pyridazine-3-one with a structure shown in the following formula and its derivative, wherein R=H, -CO2Me, -CO2Et, -CO2Bu-T, -CO2CH2Ph or -CH2Ph. The preparation method comprises: taking N-R-pyrrolidin-3-one as a starting material, and reacting it with secondary amine to generate enamine; then subjecting ethyl glyoxylate and the enamine to a nucleophilic addition reaction, and reacting its product with hydrazine directly to form an aromatic ring, thus obtaining 6-R-2, 5, 6, 7-tetrahydropyrrolo[3, 4-c] pyridazine-3-one; and removing the substituent R, thus obtaining the 2, 5, 6, 7-tetrahydropyrrolo[3, 4-c] pyridazine-3-one. After further synthesis and modification, the compound can be transformed into molecules with the potential bioactivity of treating diseases of the cardiovascular system and the central nervous system. |
| priorityDate | 2012-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.