http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102796066-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45cfb6b3b7b249b42de2e65bf75f2dea |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2012-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f91ce98be0254c9964e23a43e714f37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e8763d73d1a97e5d3491fe8a9fa97dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6af5b55ef715895e97c88781e3702cf5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4417b5d8103b522fe7ab5bf702a2d8fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f29eca5ff0381cb0607d6a3b72c03b4a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e164a8a93154c37e067695d13878807 |
| publicationDate | 2014-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102796066-B |
| titleOfInvention | Flavone compound and preparation method and application thereof |
| abstract | The invention discloses a flavone compound and a preparation method and an application thereof. The flavone compound is separated from rose, has a molecular formula C20H18O7, and a structure shown in the specifications. The preparation method of the flavone compound is characterized in that: rose is taken as a raw material, and extract extraction, silica gel column chromatography, petroleum ether-ethyl acetate column chromatography and high-pressure liquid phase chromatography separation steps are performed. The method comprises the following specific steps of: smashing rose, ultrasonically extracting with 90-99 percent ethanol, combining extracting solutions, filtering, and concentrating under reduced pressure to obtain extract; loading the extract onto a column with a silica gel dry method for performing silica gel column chromatography; gradually eluting with a chloroform-methanol solution in the volume ratio of 20:1-1:1, and combining the same parts; gradually eluting a 9:1 part with a petroleum ether-ethyl acetate solution in the volume ratio of 9:1-0:1, collecting every part of eluent, and concentrating; and further separating and purifying a 7:3 part with high-pressure liquid phase chromatography to obtain the flavone compound. The compound is simple in structure, is easy for realizing manual synthesis, has high activity, and can be taken as a pilot compound of an antitumor medicament. |
| priorityDate | 2012-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.