http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102796056-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_979cfa700e8888c6877a719918b6d1c3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-20 |
| filingDate | 2012-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e5b8525e2af5f713adae3062b316649 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a4bf8d5b4ff521028d2e02893a062a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b00fb6dcabc5c9df0d6da8d6f066b5cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e671ac39c8681454d6c7411150f521fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9e052c961c4b2c5a23c65f6e7210e13 |
| publicationDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102796056-B |
| titleOfInvention | Peramivir intermediate and preparation method for analogue |
| abstract | The invention discloses a peramivir intermediate and a preparation method for an analogue. The preparation method comprises: 1) ring-opening splitting, wherein the percentage concentration by weight of hydrogen chloride in a hydrogen chloride methanol solution is 20%-30%; 2) performing amino protection, wherein the alkaline reagent is a water-soluble carbonate solution in the reaction; 3) performing addition, cyclization and purification, including: taking the water-soluble carbonate or bicarbonate as an alkaline agent, heating, adding N-hydroxy-substituent butyl amine acyl chloride for reaction, adding sodium hydroxide for hydrolysis, acidizing again, and adding tert-butylamine for refining; 4) performing esterification after purification, including using trimethyl orthoformate to esterify with hydrochloric acid and methanol to get the peramivir intermediate and the analogue; and meanwhile performing amino protection again for the structure which is stripped the protective group in the solution under the alkaline reagent, wherein the alkaline reagent is a water-soluble carbonate solution. The preparation method is low in cost, green and environmental-friendly, and suitable for industrial mass production. The prepared intermediate product is high in purity, but the yield is relatively small. |
| priorityDate | 2012-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.