| abstract |
Provide the compound of formula (I), wherein Rn 1 , Rn 2 , Rn 3 and Rn 4 there is the implication (and described compound is as being optionally substituted of pointing out in the description) provided in the description, and medicinal ester, acid amides, solvate or salt, described compound can be used for treatment and wherein expects and/or require arrestin matter or lipid kinase (such as PIM family kinase, as PIM-1, PIM-2 and/or PIM-3) disease, and be particularly useful for Therapeutic cancer or proliferative disease.Additionally provide the combination of the compound of contained (I). |