| abstract |
The invention discloses an N-substituted pyrazolo [3, 4-d] pyrimidine ketone compound shown in Formula (I), a preparation method therefore and application thereof as an inhibitor for phosphodiesterase IX(PDEIX), wherein R' is selected from isopropyl, cyclopentyl, cyclohexyl and isobutyl; when R'' is CH3, R represents benzyl; and when R'' is H, R is selected from 3-methyl pyridine, 1-phenyl-ethyl, 1-(4-chlorophenyl) ethyl, and groups shown in the description, wherein R1 is selected from hydrogen, chloro, methoxyl, methyl, trifluoromethyl, dimethoxy, methylenedioxy and dichloro, and R2 is selected from hydrogen, methoxyl, ethoxy, isopropoxy, methyl, dimethoxy and 2-methyl-4-methoxyl. |