http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102786502-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba4d683f70804b3d4577ac4946061d47 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate | 2012-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f9d7aefcd660cfd7df44b0a2cd01de6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13d4ba9ba1c3f96a843f34e316ec4591 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_221172025fb1a6631396f7e89e366c12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7849cde7b51ad21e90afa6d3f6620e5e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e1b135538c41da9180a42836a33ad21 |
| publicationDate | 2014-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102786502-B |
| titleOfInvention | Synthesis method of taxane drug 7, 10-methoxy-docetaxel |
| abstract | The invention discloses a synthesis method of taxane drug 7, 10-methoxy-docetaxel. The synthesis method includes using 7, 10-trichloro-ethoxycarbonyl-10-deacetylbaccatin III (compound 1, CAS (chemical abstracts service) number 95603-44-4) as starting material, using triethyl silicon substrate for protection, and performing reactions of removal of protecting group of trichloro-ethoxycarbonyl, dimethyl sulfide etherification, hydrogenation reduction, removal of protecting group of the triethyl silicon substrate, side chain condensation and side chain deprotection to obtain the 7, 10-methoxy-docetaxelf with more than 99% purity. Reaction conditions are simple and mild. The synthesis method has the advantages that the required equipment is simple and is easy to operate, and methylate reagents such as highly toxic methyl iodide or dimethyl sulfate is not needed. The synthesis method is applicable to industrial production. |
| priorityDate | 2012-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 126.